A novel platform for discovery of differentially expressed microRNAs in patients with repeated implantation failure

ObjectiveTo identify predictor microRNAs (miRNAs) from patients with repeated implantation failure (RIF).DesignSystemic analysis of miRNA profiles the endometrium undergoing in vitro fertilization (IVF).SettingUniversity research institute, private IVF center, and molecular testing laboratory.Patient(s)Twenty five infertile discovery cohort 11 validation cohort.Interventions(s)None.Main Outcome Measure(s)A signature set associated risk RIF.Result(s)We designed a reproductive disease-related PanelChip to access IVF. Three major signatures, including hsa-miR-20b-5p, hsa-miR-155-5p, hsa-miR-718, were identified using infinite combination search algorithm 25 These miRNAs used as biomarkers patients. Finally, 3-miRNA was capable predicting RIF an accuracy >90%.Conclusion(s)Our findings indicated that specific endometrial can be applied diagnostic predict RIF. Such information will definitely help increase success rate practice. To (RIF). Systemic (IVF). University laboratory. Twenty cohort. None. A We >90%. Our